Mat Pyrogen Test

Pharmacies performing in house pyrogen testing.

Mat pyrogen test.

Learn more about the ctl mat kit. Try our mat kit test it all with mat biotech. Test service and diagnostic laboratories. Mat biotech s ctl mat monocyte activation test kit is helping detect endotoxin and non endotoxin pyrogens in products with an extremely low clc through its market leading 0 004 eu ml lower lod.

It mimics human reaction to pyrogens by using cryopreserved human blood making sure it s highly reliable and robust. Pyrogen testing for life changing products with an lod of 0 004 eu ml and batch sizes of up to 2 000 kits mat biotech s monocyte activation test mat kit helps big pharmaceuticals develop and release life changing products safely. In the current study 16 hsa batches were assayed for pyrogens in parallel with the rabbit pyrogen test conventional and endotoxin specific lal assay and monocyte activation test mat. The meningococcal c conjugate vaccine mencc is an interesting model with which to test the efficacy of the monocyte activation test mat as an alternative method of pyrogen testing in the quality control of vaccines.

The monocyte activation test mat can detect both endotoxin and non endotoxin pyrogens in one test. The mat is a rabbit free alternative to the rabbit pyrogen test rpt and can be used to test parenteral drugs for endotoxin and non endotoxin contaminations. Pyrogen test products with low contaminate limit concentrations. Monocytes rely on a family of pattern recognition receptors called toll like receptors tlr to identify such targets and to eliminate them by phagocytosis.

Principle of the mat the monocyte activation test mat is the human in vitroalternative to the rabbit pyrogen test and allows the detection of the full range of pyrogens including endotoxins and non endotoxin pyrogens neps. Can analyse pyrogenic activity in more complex pharmaceuticals like. Curb low endotoxin recovery ler effects. Detects all pyrogens relevant to humans.

The benefits of mat as a pyrogen test. Does not require the use of animals. Mimicks the humane immune response. Testing for pyrogens is a critical step in ensuring the safety of parenteral pharmaceutical products and medical devices.

Supported by many regulatory bodies the robust mat assay produces sensitive results based on the human immune reaction. The assay with the very lowest lod is mat biotech s ctl mat kit. Releasing products with low clcs requires an assay with a very low lower limit of detection lod.